Second-Line Pharmacotherapies: Off-Label Medication
Several new off-label agents are emerging in the literature. Off-label medications are pharmacotherapies that are not licensed by the TGA for treatment of AUD. They should be a second-line pharmacotherapy in patients who have not responded to approved pharmacotherapies for this indication. However, if first-line medications are contraindicated in patients (e.g. naltrexone/ disulfiram in patients with advanced liver disease), off-label pharmacotherapy may be considered as a first line treatment.