Topiramate
Topiramate is an anti-epileptic medication that is hypothesised to induce its effect by antagonizing glutamate activity at glutamate receptors (AMPA and kainate receptors) and inhibiting dopamine release. Topiramate has shown some superiority over placebo for reducing drinking and but more trials are needed.
| Chapter |
Recommendation |
Grade of recommendation |
| 10.18 |
Topiramate has some evidence for reducing heavy drinking. Topiramate has a complex side effect profile and further research is needed before it can be recommended as first-line treatment. |
B |