Other Medications

Chlormethiazole is a short-acting sedative and anticonvulsant medication that was widely used for treating alcohol withdrawal before the advent of benzodiazepines. It is no longer recommended for managing alcohol withdrawal due to its risk of respiratory depression and death in overdose or in combination with alcohol or other sedatives. 

Alcohol (ethanol), gamma-hydroxybutyric acid (GHB), barbiturates, beta-blockers, clonidine, or magnesium infusions have no role in managing alcohol withdrawal. 

Baclofen, a GABA-B receptor agonist, used in clinical practice as a skeletal muscle relaxant, has been shown to suppress symptoms of alcohol withdrawal in preliminary clinical studies. There is no evidence to suggest it is superior to benzodiazepines and insufficient evidence to recommend its use in treatment of alcohol withdrawal.